The triglyceride (TG) to high density lipoprotein cholesterol (HDL) ratio (TG:HDL) is directly related to insulin resistance and is a simple and easily accessible tool for the prediction of insulin sensitivity. Previous studies have found the TG:HDL ratio to be significantly associated with insulin resistance. However, more recently this association has been found to be non-significant among non- Hispanic black adults. The purpose of this study will be to examine the association of the TG:HDL ratio and insulin resistance measured via the homeostatic assessment of insulin resistance method and to determine new ratio cutoffs for non-Hispanic blacks. Data for this study will be obtained from the 2003-2004 and 2005-2006 National Health and Nutrition Examination Survey. Power analysis will be used to determine adequate sample size. Multiple linear regression analyses, controlled for age, body mass index, waist circumference, education, income, smoking status, alcohol intake, blood pressure (systolic/diastolic), and C-reactive protein, will be used to assess the relationship of the TG:HDL ratio with insulin resistance by gender and racial/ethnic group. The area under the receiving-operating characteristic curve will be use to determine the predictive value of the TG:HDL ratio for insulin resistance among non-Hispanic blacks. Participants with existing type 2 diabetes mellitus, those taking oral antiglycemic agents or insulin, and those younger than 20 years of age will be excluded from the analyses. We expect that the results from this study will further support the clinical and epidemiological use of the TG:HDL ratio as a tool to predict insulin resistance and insulin resistance co-morbidities among non-Hispanic blacks.